Exciting News! Our Latest Study on Donor Lung Injury is Published! Lung transplantation is a life-saving procedure, but the scarcity of viable donor lungs remains a major challenge. Our newly published study dives deep into three distinct donor lung injury models—infection-induced, aspiration-induced, and ventilator-induced—to unravel their molecular and functional differences.
Text: Sandra Lindstedt
.What did we find on Donor Lung Injury?
Each injury model triggered unique immune and inflammatory responses:
✅ Aspiration-induced injury → T-cell proliferation & complement suppression
✅ Ventilator-induced lung injury → Monocyte chemotaxis activation
✅ Infection-induced injury → Stress response protein activation
Key takeaway
Regardless of the injury type, extracellular matrix degradation—particularly collagen type IV breakdown and elastin upregulation—emerged as a central feature of acute lung injury. These findings point to the extracellular matrix as a critical target for lung restoration and rejuvenation!
This research brings us one step closer to expanding the donor lung pool and improving transplantation outcomes. A huge thanks to our incredible team and collaborators who made this possible!
Read the full article at PubMed here.
